Cationic Amino Acid Transport in the Rabbit Reticulocyte

Cationic amino acid transport in the rabbit reticulocyte. Na+-dependent inhibition of Na+-independent transport.

A transport system for cationic amino acids has been described for the rabbit reticulocyte. This system appears neither concentrative nor energy-dependent. At high levels, several neutral amino acids with large apolar side chains inhibit uptake by it; furthermore, the presence of external leucine accelerates lysine exodus from the cell. These effects do not, however, arise from an interaction b...

Cationic Amino Acid Transporters

We have identified the third member of a family of cationic amino acid transporters in lipopolysaccharidestimulated murine macrophages. The deduced amino acid sequence of this transporter is the same as MCAT-2 (mouse cationic amino acid transporter-Z), the low affinity transporter expressed in hepatocytes, except for a stretch of 41 amino acids that connects the eighth and ninth membrane-spanni...

Expression of Cationic Amino Acid

Reactions of neutral amino acids plus Na(+) with a cationic amino acid transport system.

Before we could understand the transport interactions between the neutral and the basic amino acids, we needed to answer four questions: 1. To what extent do diamino acids actually react with transport systems in their neutral forms? First, a,fl-diamino propionic acid, pK; = 6.7, was shown to behave in transport almost entirely as a neutral amino acid, an analogue to serine and alanine in one n...

Cationic amino acid transport in the renal medulla and blood pressure regulation.

Previous studies have indicated that NO synthesis in isolated inner medullary collecting duct cells is reduced by cationic amino acids that compete with L-arginine for cellular uptake. In the present study, we investigated the effects of chronic renal medullary infusion of cationic amino acids on renal NO concentration and mean arterial pressure (MAP) in Sprague-Dawley rats. Renal medullary inf...